i had a play with our demo s2r 1000 today. using themathesis and calling it a 1000m i adjusted the trimmer, but ithad no effect. if you went from full rich to full lean then it had no effect. the 5.9m trimmer is very fast acting, and that range would have it stall from too lean and too rich.
nothing you do with it with the sensor connected will change the mixture. altho you can change the cylinder to cylinder variation - you can have one lean and one rich, but the average of the two is always 1.5 - 2.0% CO, which is what it cycles around. you can't change the average.
with the sensor disconnected you can lean the mixture with the air bleeds, but on our demo s2r 1000 it's around 4.5% CO when it gets to 75 or so degrees, so no need to adjust it. i did balance the closed loop mixture when i did the first service so both cylinders were the same as the average, and those air bleed settings (h: full in, v: out 3/8) gave the same idle mixture setting with the sensor disconnected.