One day, no problem. I did it last year. Last 5 miles were in a downpour!
Mapquest pegs it at 6hrs and 380 miles through Grand Junction. I did a much more fun route through Moab and LaSal Junction, then east.
After last year's trip, me and a buddy decided to scrap our normal "annual guys weekend" with a bunch of other folks and stick with this. No brainer.
Yehu is planning on it and another Monster rider (non DML'er >

) is also planning on making the trip with me.